Telomere maintenance via recombination

Across TCGA patient cohorts, RNA activity of the Telomere maintenance via recombination pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TTI1_S828, CDK13_S342, and CENATAC, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telomere maintenance via recombination activity versus TTI1_S828 in GBM (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TTI1_S828 →	+0.641	+0.337	.007	.002	3	3
GBM	CDK13_S342 →	+2.333	+0.436	.003	.005	3	3
OV	CENATAC →	+2.231	+1.622	<.001	<.001	3	3
LUAD	HDGFL2_S234 →	+1.187	+0.202	<.001	<.001	3	3
LUAD	TGOLN2_S71 →	-0.518	-0.207	<.001	<.001	3	3
GBM	C1orf198 →	-0.417	-0.425	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000722 vs TTI1_S828 — GBM

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