Telomere maintenance via recombination

Across TCGA cell cohorts, RNA activity of the Telomere maintenance via recombination pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAST3, CLASRP, and ZSCAN26, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAST3 grouped by Telomere maintenance via recombination-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	MAST3 →	+0.539	+0.278	.006	.003	3	6
CNS	CLASRP →	+0.705	+0.262	.001	.002	3	4
OESOPHAGUS	ZSCAN26 →	+0.986	+0.430	.004	.001	3	4
UPPER_AERODIGESTIVE_TRACT	ZNF776 →	+1.524	+0.269	.005	.001	2	5
UPPER_AERODIGESTIVE_TRACT	AGBL5 →	+1.107	+0.238	<.001	<.001	3	4
PANCREAS	SH3GLB2 →	+0.568	+0.253	.005	.005	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAST3 by Telomere maintenance via recombination activity — KIDNEY

Explore this box plot interactively →