Telomere maintenance via recombination

Across TCGA cell cohorts, RNA activity of the Telomere maintenance via recombination pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KBTBD7, VMAC, and PRELID3B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telomere maintenance via recombination activity versus KBTBD7 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	KBTBD7 →	+0.919	+0.556	.004	.002	3	5
BLOOD_Lymphoma	VMAC →	+0.762	+0.940	.001	.003	3	5
BREAST	PRELID3B →	+0.643	+0.728	.003	.007	3	5
CNS	MYBL2 →	-1.333	-0.297	<.001	.006	3	4
UPPER_AERODIGESTIVE_TRACT	MANEAL →	+1.592	+0.338	.001	.006	3	4
UPPER_AERODIGESTIVE_TRACT	CYFIP2 →	+0.702	+0.454	.008	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000722 vs KBTBD7 — UPPER_AERODIGESTIVE_TRACT

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