Box C/D snoRNP assembly

Across TCGA patient cohorts, RNA activity of the Box C/D snoRNP assembly pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HSPH1, ZMYM2, and DHX8, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Box C/D snoRNP assembly activity versus HSPH1 in COAD (Pearson r = 0.55).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	HSPH1 →	+0.611	+0.027	<.001	<.001	3	7
LSCC	ZMYM2 →	+0.360	+0.070	<.001	<.001	3	7
LSCC	DHX8 →	+0.386	+0.065	<.001	<.001	3	7
UCEC	SNRPD2 →	+0.203	+0.075	<.001	.001	3	6
LSCC	CMSS1 →	+0.492	+0.060	<.001	<.001	3	6
LSCC	FXR1 →	+0.367	+0.055	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000492 vs HSPH1 — COAD

Explore this scatter interactively →