Box C/D snoRNP assembly

Across TCGA cell cohorts, RNA activity of the Box C/D snoRNP assembly pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTPAL, JTB, and CDK14, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TTPAL grouped by Box C/D snoRNP assembly-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TTPAL →	+1.352	+0.189	.001	.001	3	7
BREAST	JTB →	-1.140	-0.135	<.001	<.001	3	5
LUNG_NSCLC_LUSC	CDK14 →	+2.232	+0.124	.006	.007	3	5
LARGE_INTESTINE	SGMS1 →	+1.051	+0.115	.002	.005	3	5
SOFT_TISSUE	CCN2 →	+3.406	+0.125	.006	.001	3	5
LUNG_NSCLC_LUAD	DDHD2 →	+0.817	+0.112	.003	.008	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TTPAL by Box C/D snoRNP assembly activity — BLOOD_Lymphoma

Explore this box plot interactively →