Box C/D snoRNP assembly

Across TCGA cell cohorts, RNA activity of the Box C/D snoRNP assembly pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYADM, CPT2, and PIAS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MYADM grouped by Box C/D snoRNP assembly-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MYADM →	-0.248	-0.093	<.001	.001	3	5
BREAST	CPT2 →	-0.285	-0.080	<.001	<.001	3	4
BLOOD_Myeloma	PIAS1 →	+0.284	+0.086	.002	.008	3	4
KIDNEY	FHL3 →	+0.265	+0.089	<.001	.005	3	4
BLOOD_Lymphoma	SLC6A7 →	-0.361	-0.073	.008	.003	3	4
SKIN	GPR153 →	-0.180	-0.079	.004	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MYADM by Box C/D snoRNP assembly activity — BREAST

Explore this box plot interactively →