Box C/D snoRNP assembly

Across TCGA cell cohorts, RNA activity of the Box C/D snoRNP assembly pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DUSP7, TIMM50, and NUPR1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Box C/D snoRNP assembly activity versus DUSP7 in KIDNEY (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	DUSP7 →	+1.572	+0.208	.003	.001	3	4
LUNG_NSCLC_LUSC	TIMM50 →	-0.944	-0.107	.002	.009	3	4
OVARY	NUPR1 →	-2.894	-0.096	.004	.001	2	5
OVARY	MRPL43 →	+0.804	+0.125	.005	.007	3	4
LIVER	DTD1 →	+0.629	+0.161	.004	.001	3	4
UPPER_AERODIGESTIVE_TRACT	PAF1 →	-0.762	-0.103	.009	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000492 vs DUSP7 — KIDNEY

Explore this scatter interactively →