"Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"

Across TCGA cell cohorts, RNA activity of the "Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)" pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPP40, TBL3, and DIP2A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPP40 grouped by "Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RPP40 →	-0.425	-0.374	.005	<.001	3	6
CNS	TBL3 →	-0.380	-0.321	<.001	<.001	3	6
LUNG_NSCLC_LUSC	DIP2A →	-0.250	-0.204	.002	.005	3	5
CNS	RGSL1 →	+0.162	+0.290	.005	<.001	2	6
OVARY	CD109 →	-0.238	-0.282	<.001	<.001	3	5
PANCREAS	GLUD2 →	+0.235	+0.172	.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPP40 by "Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)" activity — OVARY

Explore this box plot interactively →