"Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"

Across TCGA pan-cancer cohorts, RNA activity of the "Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)" pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 17 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher "Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)" pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and READ, show the opposite pattern, with higher activity associated with better survival.

KIRC, KIRP, and LIHC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.555	0.700	<.001	186	view →
KIRP	DFS	Tertile	All	0.772	0.926	<.001	73	view →
LIHC	DFS	Median	All	0.464	0.602	<.001	60	view →
UCS	DFS	Tertile	II,III,IV	0.542	0.158	.006	52	view →
ACC	DFS	Quartile	All	0.222	0.779	.001	47	view →
UCEC	DFS	Median	All	0.786	0.886	<.001	34	view →
READ	OS	Quartile	II,III,IV	0.940	0.453	.001	32	view →
UVM	DFS	Median	III,IV	0.274	0.661	.001	31	view →
LGG	DFS	Median	All	0.778	0.878	<.001	30	view →
LUSC	DFS	Tertile	III,IV	0.148	0.897	.001	17	view →
THYM	DFS	Tertile	All	1.000	0.819	.011	17	view →
CESC	DFS	Median	III,IV	0.221	0.595	.026	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0000479–KIRC (OS)

Open the KIRC breakdown →