"Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"

Across TCGA cell cohorts, RNA activity of the "Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)" pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADCK5, PIAS3, and HINT2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ADCK5 grouped by "Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ADCK5 →	-0.478	-0.304	.006	.004	2	5
OESOPHAGUS	PIAS3 →	+0.721	+0.185	.002	.001	2	5
SOFT_TISSUE	HINT2 →	-0.981	-0.336	.006	<.001	2	4
KIDNEY	IDH1 →	-1.071	-0.341	.002	<.001	3	3
SOFT_TISSUE	APOBEC3H →	+0.488	+0.311	.004	<.001	3	3
SOFT_TISSUE	MAIP1 →	+0.504	+0.259	.004	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ADCK5 by "Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)" activity — SOFT_TISSUE

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