"Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"

Across TCGA cell cohorts, RNA activity of the "Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)" pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB1B, RNPEPL1, and RNASEL, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)" activity versus RAB1B in BREAST (Pearson r = -0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	RAB1B →	-0.862	-0.284	.003	<.001	3	6
BLOOD_Leukemia	RNPEPL1 →	-0.628	-0.443	.002	.007	3	5
LARGE_INTESTINE	RNASEL →	-0.667	-0.288	.003	.001	3	5
LIVER	PBX1 →	-3.362	-0.355	.001	.009	3	5
BREAST	MAPK3 →	-0.783	-0.217	.003	.003	3	5
BREAST	REEP5 →	-1.062	-0.235	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000479 vs RAB1B — BREAST

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