"Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"

Across TCGA cell cohorts, RNA activity of the "Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)" pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC12A4, SERTAD1, and C8orf33, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC12A4 grouped by "Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SLC12A4 →	+0.698	+0.137	.002	<.001	3	5
LARGE_INTESTINE	SERTAD1 →	+0.945	+0.127	.001	.003	3	4
URINARY_TRACT	C8orf33 →	-0.536	-0.214	.005	.007	3	4
OESOPHAGUS	DNAJB5 →	+1.075	+0.179	<.001	<.001	3	4
SKIN	MMP21 →	-0.040	-0.164	.006	.001	3	4
OVARY	RAB4A →	-0.870	-0.242	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC12A4 by "Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)" activity — PANCREAS

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