Maturation of 5.8S rRNA

Across TCGA patient cohorts, RNA activity of the Maturation of 5.8S rRNA pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPRD2, CSTF1, and NUP153, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maturation of 5.8S rRNA activity versus RPRD2 in LSCC (Pearson r = 0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RPRD2 →	+0.244	+0.056	<.001	<.001	3	6
PDAC	CSTF1 →	+0.237	+0.033	<.001	<.001	3	6
LSCC	NUP153 →	+0.264	+0.069	<.001	<.001	3	6
LSCC	PRCC →	+0.203	+0.035	<.001	<.001	3	6
LSCC	DBR1 →	+0.242	+0.036	<.001	<.001	3	6
LSCC	EED →	+0.218	+0.044	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000460 vs RPRD2 — LSCC

Explore this scatter interactively →