Maturation of 5.8S rRNA

Across TCGA cell cohorts, RNA activity of the Maturation of 5.8S rRNA pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LXN, FAM122C, and DYNC1I2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LXN grouped by Maturation of 5.8S rRNA-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	LXN →	-4.575	-0.421	.001	<.001	3	4
KIDNEY	FAM122C →	-0.588	-0.443	.002	<.001	3	4
STOMACH	DYNC1I2 →	-0.738	-0.225	.005	.008	3	3
PANCREAS	WWP1 →	-0.618	-0.187	<.001	.001	2	4
PANCREAS	PPP1R12A →	-0.858	-0.196	<.001	<.001	3	3
LUNG_NSCLC_LUAD	PCIF1 →	-0.539	-0.165	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LXN by Maturation of 5.8S rRNA activity — SOFT_TISSUE

Explore this box plot interactively →