Autophagy of mitochondrion

Across TCGA cell cohorts, RNA activity of the Autophagy of mitochondrion pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are B3GALT4, ACBD5, and ARPC1A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, B3GALT4 grouped by Autophagy of mitochondrion-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	B3GALT4 →	+0.525	+0.218	.002	.002	3	4
URINARY_TRACT	ACBD5 →	+0.786	+0.148	.001	.007	3	4
BLOOD_Leukemia	ARPC1A →	-0.942	-0.165	.002	.005	3	4
BONE	FCGBP →	+2.504	+0.285	.009	.009	3	4
BLOOD_Myeloma	AMN1 →	+0.907	+0.308	<.001	.006	3	4
BLOOD_Leukemia	PPP1R35 →	-0.860	-0.261	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

B3GALT4 by Autophagy of mitochondrion activity — CNS

Explore this box plot interactively →