RNA 5'-splice site recognition

Across TCGA cell cohorts, RNA activity of the RNA 5'-splice site recognition pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WASF1, PSIP1, and SLC35C1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA 5'-splice site recognition activity versus WASF1 in BREAST (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	WASF1 →	+1.079	+0.240	.002	.001	3	6
BREAST	PSIP1 →	+1.068	+0.185	<.001	<.001	3	5
PANCREAS	SLC35C1 →	-1.054	-0.210	.004	.001	3	5
STOMACH	LRRC8C →	+1.842	+0.296	<.001	.001	3	5
BREAST	NLGN2 →	+1.363	+0.262	.007	.003	3	5
BONE	PPP2R5B →	-1.303	-0.139	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000395 vs WASF1 — BREAST

Explore this scatter interactively →