mRNA 3'-splice site recognition

Across TCGA patient cohorts, RNA activity of the mRNA 3'-splice site recognition pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HEPH, YAP1, and EVI5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, mRNA 3'-splice site recognition activity versus HEPH in GBM (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HEPH →	-0.823	-0.234	.005	<.001	3	4
BRCA	YAP1 →	-0.990	-0.201	<.001	<.001	3	4
BRCA	EVI5 →	-0.430	-0.139	.001	.008	3	4
PDAC	HOPX →	-0.683	-0.215	<.001	<.001	3	3
PDAC	R3HDM2P1 →	-0.138	-0.119	<.001	.004	3	3
CCRCC	RBKS →	-0.455	-0.106	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000389 vs HEPH — GBM

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