mRNA 3'-splice site recognition

Across TCGA cell cohorts, RNA activity of the mRNA 3'-splice site recognition pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EP400, KIAA1549L, and SUDS3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EP400 grouped by mRNA 3'-splice site recognition-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	EP400 →	+0.535	+0.085	.008	.002	3	4
CNS	KIAA1549L →	-1.514	-0.094	.003	.002	3	3
BREAST	SUDS3 →	+0.987	+0.101	<.001	<.001	3	3
BREAST	C2CD5 →	+0.830	+0.104	<.001	<.001	3	3
BREAST	RHBG →	+0.900	+0.067	.003	.001	3	3
BREAST	COG6 →	+0.646	+0.101	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EP400 by mRNA 3'-splice site recognition activity — BREAST

Explore this box plot interactively →