Spliceosomal snRNP assembly

Across TCGA patient cohorts, RNA activity of the Spliceosomal snRNP assembly pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RRP9, EPAS1, and SPDYE22P, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spliceosomal snRNP assembly activity versus RRP9 in GBM (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RRP9 →	+0.429	+0.270	<.001	<.001	3	6
LSCC	EPAS1 →	-0.860	-0.266	<.001	<.001	3	6
LSCC	SPDYE22P →	+0.404	+0.236	.001	<.001	3	6
GBM	NDC1 →	+0.585	+0.204	<.001	<.001	3	6
GBM	CDK2 →	+0.661	+0.251	<.001	<.001	3	5
LSCC	KIAA0513 →	-0.707	-0.256	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000387 vs RRP9 — GBM

Explore this scatter interactively →