Spliceosomal snRNP assembly

Across TCGA cell cohorts, RNA activity of the Spliceosomal snRNP assembly pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM9B, TTPAL, and ACVR2B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM9B grouped by Spliceosomal snRNP assembly-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TMEM9B →	+0.679	+0.252	.002	.006	3	5
BREAST	TTPAL →	+0.747	+0.133	.001	.005	3	4
BLOOD_Leukemia	ACVR2B →	-0.804	-0.168	.002	<.001	3	4
KIDNEY	CYRIB →	-0.732	-0.288	<.001	.001	3	4
LIVER	RECQL4 →	-0.990	-0.316	.003	<.001	3	4
LIVER	CDT1 →	-0.536	-0.259	.006	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM9B by Spliceosomal snRNP assembly activity — SOFT_TISSUE

Explore this box plot interactively →