"Regulation of alternative mRNA splicing, via spliceosome"

Across TCGA patient cohorts, RNA activity of the "Regulation of alternative mRNA splicing, via spliceosome" pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLIRP, LRPPRC, and MRPL16, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of alternative mRNA splicing, via spliceosome" activity versus SLIRP in BRCA (Pearson r = -0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SLIRP →	-0.390	-0.042	<.001	<.001	3	6
BRCA	LRPPRC →	-0.362	-0.025	<.001	.005	3	5
LSCC	MRPL16 →	-0.327	-0.040	<.001	<.001	3	5
LUAD	MRPL46 →	-0.245	-0.036	<.001	<.001	3	5
GBM	USF1 →	+0.429	+0.052	<.001	<.001	3	5
GBM	GATAD2B →	+0.369	+0.039	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000381 vs SLIRP — BRCA

Explore this scatter interactively →