"Regulation of alternative mRNA splicing, via spliceosome"

Across TCGA cell cohorts, RNA activity of the "Regulation of alternative mRNA splicing, via spliceosome" pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GUK1, SLC2A4RG, and CECR2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GUK1 grouped by "Regulation of alternative mRNA splicing, via spliceosome"-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GUK1 →	-0.142	-0.064	.003	<.001	3	5
BREAST	SLC2A4RG →	+0.129	+0.071	.006	.003	3	4
LUNG_NSCLC_LUAD	CECR2 →	+0.228	+0.127	.002	<.001	3	4
STOMACH	NOP53 →	-0.448	-0.084	.001	.001	3	4
SOFT_TISSUE	BRPF1 →	-0.265	-0.087	.001	.003	3	4
BLOOD_Leukemia	EPB41L1 →	-0.149	-0.091	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GUK1 by "Regulation of alternative mRNA splicing, via spliceosome" activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →