Formation of quadruple SL/U4/U5/U6 snRNP

pathway activity — cross-omics
GO:0000353Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Formation of quadruple SL/U4/U5/U6 snRNP pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARID4A_S159, ARID4A_S160, and ANXA2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCARID4A_S159 →-0.516-0.065<.001.00634
LSCCARID4A_S160 →-0.516-0.065<.001.00634
UCECANXA2 →-0.315-0.098.006.00434
LSCCSQLE →-0.351-0.063.001.00234
LSCCC8orf37_S96 →+0.728+0.090.003.00234
LSCCEHMT2_S246 →+0.334+0.078.004.00134
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration