Response to oxygen radical

Across TCGA cell cohorts, RNA activity of the Response to oxygen radical pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIMM17A, COLGALT1, and ARHGEF25, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TIMM17A grouped by Response to oxygen radical-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TIMM17A →	-0.792	-1.213	<.001	<.001	3	4
OVARY	COLGALT1 →	-0.938	-1.663	.002	<.001	3	4
STOMACH	ARHGEF25 →	-1.893	-0.883	.006	.003	3	4
BLOOD_Myeloma	KIAA0040 →	+1.191	+0.934	.009	.007	3	4
UPPER_AERODIGESTIVE_TRACT	SMPDL3B →	+1.150	+1.409	<.001	<.001	3	4
BREAST	TLCD3A →	-1.003	-0.798	.005	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TIMM17A by Response to oxygen radical activity — OESOPHAGUS

Explore this box plot interactively →