Response to reactive oxygen species

Across TCGA cell cohorts, RNA activity of the Response to reactive oxygen species pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGEF25, RBBP6, and GALNT6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to reactive oxygen species activity versus ARHGEF25 in KIDNEY (Pearson r = 0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ARHGEF25 →	+2.626	+0.248	<.001	<.001	3	5
SOFT_TISSUE	RBBP6 →	+1.322	+0.266	<.001	.009	3	5
LUNG_SCLC	GALNT6 →	-1.508	-0.160	.005	.002	3	5
BLOOD_Lymphoma	HNRNPD →	+0.834	+0.136	.001	.008	3	5
BLOOD_Lymphoma	SLC22A4 →	-1.190	-0.150	.001	.002	3	5
LUNG_NSCLC_LUAD	TMPRSS11E →	-1.425	-0.115	.008	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000302 vs ARHGEF25 — KIDNEY

Explore this scatter interactively →