"Retrograde transport, vesicle recycling within Golgi"

Across TCGA patient cohorts, RNA activity of the "Retrograde transport, vesicle recycling within Golgi" pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COG3, BOLA3-AS1, and SAR1B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Retrograde transport, vesicle recycling within Golgi" activity versus COG3 in COAD (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	COG3 →	+0.277	+0.149	.004	.002	3	4
UCEC	BOLA3-AS1 →	-0.502	-0.191	<.001	<.001	3	4
BRCA	SAR1B →	+0.494	+0.210	.002	<.001	3	4
BRCA	FBP1 →	+0.880	+0.149	.008	.008	3	4
BRCA	IBA57-DT →	-0.486	-0.187	.002	.002	3	4
OV	PMPCB →	-0.293	-0.089	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000301 vs COG3 — COAD

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