"Retrograde transport, vesicle recycling within Golgi"

Across TCGA cell cohorts, RNA activity of the "Retrograde transport, vesicle recycling within Golgi" pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DMAC2, TRIP11, and SMIM14, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Retrograde transport, vesicle recycling within Golgi" activity versus DMAC2 in URINARY_TRACT (Pearson r = -0.84).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	DMAC2 →	-0.676	-0.498	.006	<.001	3	5
LUNG_NSCLC_LUAD	TRIP11 →	+0.569	+0.511	.001	.002	3	5
SKIN	SMIM14 →	+0.765	+0.263	.004	.006	3	5
OESOPHAGUS	REC8 →	+1.453	+0.389	.003	.003	3	4
URINARY_TRACT	SLC35B4 →	-0.890	-0.444	.001	.002	3	4
STOMACH	C14orf28 →	+0.550	+0.500	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000301 vs DMAC2 — URINARY_TRACT

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