Deadenylation-dependent decapping of nuclear-transcribed mRNA

Across TCGA patient cohorts, RNA activity of the Deadenylation-dependent decapping of nuclear-transcribed mRNA pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DCPS, RNF214, and ZNF704_S77, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Deadenylation-dependent decapping of nuclear-transcribed mRNA activity versus DCPS in HNSC (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DCPS →	+0.340	+0.064	<.001	.002	3	6
LSCC	RNF214 →	+0.194	+0.062	<.001	<.001	3	5
LUAD	ZNF704_S77 →	+0.687	+0.030	.003	.009	3	5
LUAD	AHNAK2_S260 →	-1.275	-0.037	.004	.005	3	5
HNSC	RFX5 →	+0.424	+0.070	<.001	<.001	3	5
CCRCC	FOSL2_S120 →	-0.511	-0.033	<.001	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000290 vs DCPS — HNSC

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