Deadenylation-dependent decapping of nuclear-transcribed mRNA

Across TCGA pan-cancer cohorts, RNA activity of the Deadenylation-dependent decapping of nuclear-transcribed mRNA pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 11 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher Deadenylation-dependent decapping of nuclear-transcribed mRNA pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BRCA and SCLC, show the opposite pattern, with higher activity associated with better survival.

KIRC, MESO, and KIRP are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Quartile	IV	0.199	0.714	<.001	97	view →
MESO	OS	Median	All	0.251	0.504	<.001	84	view →
KIRP	DFS	Median	All	0.505	0.653	<.001	81	view →
ACC	DFS	Tertile	IV	0.130	0.601	.001	47	view →
BLCA	OS	Quartile	IV	0.144	0.476	<.001	35	view →
BRCA	DFS	Median	III,IV	0.927	0.824	.003	33	view →
STAD	DFS	Quartile	All	0.574	0.818	.015	32	view →
SCLC	OS	Median	III,IV	0.752	0.494	.008	24	view →
DLBC	DFS	Quartile	All	0.187	0.859	.002	22	view →
UVM	DFS	Median	III,IV	0.208	0.740	.006	14	view →
KICH	OS	Quartile	All	0.602	1.000	.031	13	view →
THYM	OS	Median	All	0.981	0.729	.012	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0000290–KIRC (DFS)

Open the KIRC breakdown →