Deadenylation-dependent decapping of nuclear-transcribed mRNA

Across TCGA patient cohorts, RNA activity of the Deadenylation-dependent decapping of nuclear-transcribed mRNA pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPIHBP1, BMERB1, and S1PR1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Deadenylation-dependent decapping of nuclear-transcribed mRNA activity versus GPIHBP1 in GBM (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GPIHBP1 →	-0.829	-0.232	<.001	.005	3	4
BRCA	BMERB1 →	-1.073	-0.211	.003	.006	3	4
GBM	S1PR1 →	-0.649	-0.131	.002	.007	3	4
GBM	SLC9A3R2 →	-0.318	-0.255	.002	.002	3	4
GBM	GTSE1 →	+0.822	+0.231	<.001	.005	3	4
GBM	NUP50 →	+0.295	+0.221	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000290 vs GPIHBP1 — GBM

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