Deadenylation-dependent decapping of nuclear-transcribed mRNA

Across TCGA cell cohorts, RNA activity of the Deadenylation-dependent decapping of nuclear-transcribed mRNA pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAF4, NOB1, and THBS1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Deadenylation-dependent decapping of nuclear-transcribed mRNA activity versus TAF4 in LIVER (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TAF4 →	+0.638	+0.371	.001	<.001	3	7
BONE	NOB1 →	+0.846	+0.350	<.001	<.001	3	7
LIVER	THBS1 →	-4.754	-0.411	.006	.007	3	5
STOMACH	RCOR2 →	+2.504	+0.313	.001	.004	3	5
LUNG_SCLC	ZFP90 →	+0.969	+0.171	<.001	.001	3	5
BONE	CLPP →	+0.958	+0.332	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000290 vs TAF4 — LIVER

Explore this scatter interactively →