Deadenylation-dependent decapping of nuclear-transcribed mRNA

Across TCGA cell cohorts, RNA activity of the Deadenylation-dependent decapping of nuclear-transcribed mRNA pathway is significantly associated with the protein abundance of multiple proteins, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LSM1, PPM1G, and EDC4, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Deadenylation-dependent decapping of nuclear-transcribed mRNA activity versus LSM1 in OVARY (Pearson r = 0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	LSM1 →	+1.572	+0.208	<.001	.002	3	17
LARGE_INTESTINE	PPM1G →	+1.359	+0.285	<.001	<.001	3	16
SOFT_TISSUE	EDC4 →	+0.888	+0.376	<.001	<.001	3	15
LARGE_INTESTINE	PSMB6 →	+1.456	+0.272	<.001	.001	3	15
LARGE_INTESTINE	UBA2 →	+1.745	+0.309	<.001	<.001	3	14
SOFT_TISSUE	LSM7 →	+1.103	+0.378	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000290 vs LSM1 — OVARY

Explore this scatter interactively →