"Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"

Across TCGA patient cohorts, RNA activity of the "Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DOP1B_S1021, POGZ, and RAB3D, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" activity versus DOP1B_S1021 in GBM (Pearson r = -0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DOP1B_S1021 →	-0.712	-0.032	.002	.006	3	7
HNSC	POGZ →	+0.338	+0.104	<.001	<.001	3	6
UCEC	RAB3D →	-0.555	-0.064	.006	.005	3	6
LUAD	TOP2B →	+0.188	+0.032	.005	.002	3	5
UCEC	DHX32 →	-0.390	-0.075	<.001	.004	2	6
GBM	PSIP1 →	+0.771	+0.038	<.001	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000288 vs DOP1B_S1021 — GBM

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