"Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"

Across TCGA patient cohorts, RNA activity of the "Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PBLD, ASCC3, and ACY3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" activity versus PBLD in PDAC (Pearson r = -0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PBLD →	-0.705	-0.154	<.001	.001	3	3
PDAC	ASCC3 →	+0.226	+0.124	.002	.002	3	3
PDAC	ACY3 →	-0.730	-0.137	<.001	.001	3	3
BRCA	KIF12 →	-1.751	-0.209	.001	<.001	3	3
PDAC	SLC28A2 →	-0.875	-0.146	.002	.001	3	3
PDAC	ADAMTSL3 →	-0.667	-0.155	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000288 vs PBLD — PDAC

Explore this scatter interactively →