"Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"

Across TCGA cell cohorts, RNA activity of the "Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBM4, GANAB, and ZNF574, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RBM4 grouped by "Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	RBM4 →	-0.821	-0.181	.006	.002	3	4
OVARY	GANAB →	-0.415	-0.276	.002	.007	3	3
SKIN	ZNF574 →	-0.489	-0.365	<.001	.004	3	3
SOFT_TISSUE	TECR →	-0.659	-0.326	<.001	.008	3	3
STOMACH	IFIH1 →	+1.951	+0.309	.004	.001	3	3
STOMACH	TMEM9B →	+0.808	+0.204	.006	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RBM4 by "Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →