Mitotic cytokinesis

Across TCGA patient cohorts, RNA activity of the Mitotic cytokinesis pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TACC3_S71, RFC1_T506, and RRM2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic cytokinesis activity versus TACC3_S71 in LUAD (Pearson r = 0.58).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TACC3_S71 →	+1.181	+0.066	<.001	<.001	3	8
LUAD	RFC1_T506 →	+1.206	+0.084	<.001	<.001	3	8
LUAD	RRM2 →	+0.900	+0.080	<.001	<.001	3	8
LUAD	SMC2 →	+0.657	+0.079	<.001	<.001	3	8
LUAD	SMC4 →	+0.653	+0.081	<.001	<.001	3	8
LUAD	CDK1 →	+1.020	+0.083	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000281 vs TACC3_S71 — LUAD

Explore this scatter interactively →