Mitotic cytokinesis

Across TCGA patient cohorts, RNA activity of the Mitotic cytokinesis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHEK1, ZNF695, and CDK1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic cytokinesis activity versus CHEK1 in BRCA (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CHEK1 →	+0.886	+0.168	.002	<.001	3	3
BRCA	ZNF695 →	+0.675	+0.172	.003	.001	3	3
OV	CDK1 →	+1.160	+0.223	<.001	<.001	3	3
BRCA	CGRRF1 →	-0.747	-0.172	.001	.002	3	2
BRCA	NFATC2 →	-0.893	-0.166	.001	.001	3	2
BRCA	ZNF862 →	-0.705	-0.155	.007	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000281 vs CHEK1 — BRCA

Explore this scatter interactively →