Polysaccharide biosynthetic process

Across TCGA patient cohorts, RNA activity of the Polysaccharide biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ENPP1, SDC2, and SRPX2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Polysaccharide biosynthetic process activity versus ENPP1 in OV (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ENPP1 →	+0.832	+0.055	<.001	<.001	3	6
LSCC	SDC2 →	+0.505	+0.033	.004	.001	3	6
OV	SRPX2 →	+0.792	+0.039	.003	.004	2	7
LSCC	TLN2 →	+0.493	+0.048	<.001	<.001	3	6
LSCC	SGCD →	+0.522	+0.042	<.001	<.001	3	5
LSCC	LOXL2 →	+0.598	+0.035	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000271 vs ENPP1 — OV

Explore this scatter interactively →