Polysaccharide biosynthetic process

Across TCGA cell cohorts, RNA activity of the Polysaccharide biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZMAT3, CDKL1, and ITGB1BP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Polysaccharide biosynthetic process activity versus ZMAT3 in LIVER (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ZMAT3 →	+1.014	+0.299	<.001	.004	3	5
BREAST	CDKL1 →	+2.031	+0.366	<.001	<.001	3	4
URINARY_TRACT	ITGB1BP1 →	+1.017	+0.492	.008	.005	3	4
BLOOD_Leukemia	TBC1D1 →	+1.441	+0.300	<.001	<.001	3	4
URINARY_TRACT	PTPRG →	+2.615	+0.521	.003	.001	3	4
URINARY_TRACT	DDX41 →	+0.637	+0.440	.003	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000271 vs ZMAT3 — LIVER

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