Mitochondrial fission

Across TCGA cell cohorts, RNA activity of the Mitochondrial fission pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MED12L, EAF2, and IER3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial fission activity versus MED12L in URINARY_TRACT (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	MED12L →	+0.955	+0.973	.004	.002	3	3
BLOOD_Leukemia	EAF2 →	+1.214	+0.417	<.001	.006	3	3
SOFT_TISSUE	IER3 →	-3.719	-0.310	.002	<.001	3	3
BREAST	CMAS →	+0.614	+0.534	.003	<.001	3	3
BREAST	ACVR1B →	+0.721	+0.483	.002	.009	3	3
URINARY_TRACT	FBXO24 →	+0.441	+1.202	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000266 vs MED12L — URINARY_TRACT

Explore this scatter interactively →