Spliceosomal complex assembly

Across TCGA patient cohorts, RNA activity of the Spliceosomal complex assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UCHL1, ADAR, and POGZ, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spliceosomal complex assembly activity versus UCHL1 in LSCC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	UCHL1 →	+1.261	+0.046	<.001	<.001	3	7
LSCC	ADAR →	+0.262	+0.040	.005	.004	3	6
HNSC	POGZ →	+0.382	+0.111	<.001	<.001	3	6
LSCC	DAXX →	+0.247	+0.034	.003	.006	3	6
OV	PHLDB1_S419 →	+0.573	+0.027	<.001	.003	3	5
LSCC	SMARCC2 →	+0.155	+0.044	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000245 vs UCHL1 — LSCC

Explore this scatter interactively →