Spliceosomal complex assembly

Across TCGA pan-cancer cohorts, RNA activity of the Spliceosomal complex assembly pathway is associated with patient survival in 26 of 34 cancer lineages. Pathway activity is summarized from the expression of its 91 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher Spliceosomal complex assembly pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and BRCA, show the opposite pattern, with higher activity associated with better survival.

KIRC, KIRP, and UCEC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.552	0.687	<.001	100	view →
KIRP	DFS	Median	All	0.354	0.736	<.001	81	view →
UCEC	DFS	Median	All	0.788	0.880	.001	74	view →
ACC	OS	Quartile	All	0.582	0.936	<.001	69	view →
UCS	DFS	Tertile	II,III,IV	0.605	0.181	<.001	56	view →
UVM	DFS	Quartile	All	0.234	0.670	.001	54	view →
LIHC	DFS	Tertile	All	0.311	0.476	<.001	48	view →
PRAD	DFS	Median	All	0.713	0.819	<.001	36	view →
BRCA	DFS	Tertile	III,IV	0.896	0.713	.002	35	view →
THCA	DFS	Quartile	II,III,IV	0.725	0.936	<.001	26	view →
THYM	DFS	Quartile	II,III,IV	1.000	0.454	.007	24	view →
LAML	DFS	Quartile	All	0.635	0.247	.020	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GO:0000245–KIRC (DFS)

Open the KIRC breakdown →