Spliceosomal complex assembly

Across TCGA patient cohorts, RNA activity of the Spliceosomal complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZCCHC24, ASPM, and COLEC12, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spliceosomal complex assembly activity versus ZCCHC24 in BRCA (Pearson r = -0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ZCCHC24 →	-1.203	-0.341	<.001	<.001	3	6
BRCA	ASPM →	+1.218	+0.350	<.001	<.001	3	6
OV	COLEC12 →	-0.844	-0.281	<.001	<.001	3	6
BRCA	CAVIN1 →	-1.090	-0.324	<.001	<.001	3	6
PDAC	TMEM97 →	+0.733	+0.182	<.001	.001	3	6
HNSC	PRC1 →	+0.316	+0.258	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000245 vs ZCCHC24 — BRCA

Explore this scatter interactively →