Spliceosomal complex assembly

Across TCGA cell cohorts, RNA activity of the Spliceosomal complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM126A, ZNF564, and RNF11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAM126A grouped by Spliceosomal complex assembly-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	FAM126A →	+1.450	+0.192	.007	.005	3	5
SKIN	ZNF564 →	+0.440	+0.186	.008	.002	3	5
LUNG_NSCLC_LUSC	RNF11 →	+1.288	+0.234	.007	.002	2	5
CNS	COL8A1 →	+4.076	+0.228	.001	.005	3	4
BLOOD_Myeloma	APOBEC3C →	+1.594	+0.145	.003	<.001	3	4
LUNG_NSCLC_LUSC	AGO2 →	-0.893	-0.184	.003	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAM126A by Spliceosomal complex assembly activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →