Spliceosomal tri-snRNP complex assembly

Across TCGA patient cohorts, RNA activity of the Spliceosomal tri-snRNP complex assembly pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PGK1_S203, TNS2_S931, and RPS8_T130, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spliceosomal tri-snRNP complex assembly activity versus PGK1_S203 in PDAC (Pearson r = 0.05).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PGK1_S203 →	-0.707	-0.043	.002	.003	3	6
UCEC	TNS2_S931 →	+0.606	+0.072	<.001	.002	3	6
LUAD	RPS8_T130 →	-0.484	-0.028	.002	.007	3	6
LSCC	BRD9_T103 →	+0.437	+0.049	<.001	.001	3	5
LSCC	HK2 →	-0.616	-0.057	<.001	<.001	3	5
LSCC	TXNL1_S9 →	-1.036	-0.052	.003	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000244 vs PGK1_S203 — PDAC

Explore this scatter interactively →