Spliceosomal tri-snRNP complex assembly

Across TCGA cell cohorts, RNA activity of the Spliceosomal tri-snRNP complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBTB39, SENP1, and GCN1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spliceosomal tri-snRNP complex assembly activity versus ZBTB39 in BLOOD_Leukemia (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZBTB39 →	+0.972	+0.227	<.001	.001	3	8
BLOOD_Leukemia	SENP1 →	+1.086	+0.221	<.001	.001	3	8
KIDNEY	GCN1 →	+1.365	+0.607	.006	.002	3	7
LARGE_INTESTINE	SART3 →	+0.561	+0.201	.002	<.001	3	7
BREAST	NUP107 →	+0.580	+0.252	.007	<.001	3	7
LUNG_NSCLC_LUSC	NME2 →	+0.974	+0.322	.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000244 vs ZBTB39 — BLOOD_Leukemia

Explore this scatter interactively →