Protein polyubiquitination

Across TCGA cell cohorts, RNA activity of the Protein polyubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MZT2B, MZT2A, and ASPRV1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein polyubiquitination activity versus MZT2B in OVARY (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MZT2B →	+1.081	+1.316	<.001	<.001	3	5
OVARY	MZT2A →	+1.055	+1.316	.001	<.001	3	5
BLOOD_Myeloma	ASPRV1 →	+0.530	+0.172	.002	<.001	3	4
BLOOD_Myeloma	TOX4 →	+0.692	+0.172	.003	<.001	3	4
OVARY	ROBO1 →	+3.198	+1.543	.004	<.001	3	4
OESOPHAGUS	PPA1 →	+1.352	+1.710	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000209 vs MZT2B — OVARY

Explore this scatter interactively →