"Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"

Across TCGA patient cohorts, RNA activity of the "Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL26, HNRNPUL1, and NCOA5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" activity versus RPL26 in HNSC (Pearson r = -0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RPL26 →	-0.528	-0.110	<.001	<.001	3	6
HNSC	HNRNPUL1 →	+0.254	+0.111	<.001	<.001	3	6
HNSC	NCOA5 →	+0.311	+0.101	<.001	<.001	3	6
PDAC	RPL13_S140 →	-0.531	-0.043	.007	<.001	3	6
BRCA	LRP1 →	+0.518	+0.035	<.001	<.001	3	6
HNSC	RCOR3 →	+0.344	+0.078	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000184 vs RPL26 — HNSC

Explore this scatter interactively →