Sulfur amino acid transport

Across TCGA cell cohorts, RNA activity of the Sulfur amino acid transport pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SIRPA, LRRC26, and HDAC6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SIRPA grouped by Sulfur amino acid transport-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SIRPA →	-0.146	-0.170	<.001	<.001	3	5
LARGE_INTESTINE	LRRC26 →	+0.134	+0.245	.006	.002	3	4
LARGE_INTESTINE	HDAC6 →	+0.206	+0.323	<.001	<.001	3	3
OESOPHAGUS	ZCWPW1 →	+0.100	+0.148	.006	.002	3	3
OESOPHAGUS	CCN5 →	+0.141	+0.187	.002	.006	3	3
LUNG_NSCLC_LUAD	PMS1 →	-0.235	-0.278	.005	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SIRPA by Sulfur amino acid transport activity — OESOPHAGUS

Explore this box plot interactively →