Sulfur amino acid catabolic process

Across TCGA patient cohorts, RNA activity of the Sulfur amino acid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CIDEC, PPP1R14B, and XRCC6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sulfur amino acid catabolic process activity versus CIDEC in BRCA (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CIDEC →	+1.599	+0.143	<.001	.001	3	4
BRCA	PPP1R14B →	-0.533	-0.125	.004	.001	3	3
CCRCC	XRCC6 →	-0.165	-0.088	.001	.006	3	3
BRCA	CCNA1 →	-0.848	-0.141	.001	<.001	3	3
OV	ACSM5 →	+0.441	+0.076	.003	.005	3	3
HNSC	LTO1 →	-0.822	-0.111	.003	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000098 vs CIDEC — BRCA

Explore this scatter interactively →